Q: Should I buy a wood combed or a plastic combed harmonica?

A: This is a matter of personal preference. Some people like wood, some
people like plastic. Try them both and form your own opinion — BB

Each tends to produce a certain tone or timbre that is identifiable to a
trained ear. Some people have called the tone of the wood bodied
harmonicas more ~clarinet like~ than the plastic bodied. Other variables
are the reed construction and dimensions, that of the reed plate to which
the reeds are attached, and also the cover plates — HA